New research suggests that people who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide may regain lost weight much more quickly than those who end traditional lifestyle regimens.
Research printed in a major medical journal shows that while obese individuals often shed about a fifth of their body weight while undergoing treatment, the weight returns at an estimated rate of 0.8 kg per month once they quit.
"Users using these treatments should be informed of the risk of rapid weight regain when the treatment is stopped," cautioned researcher Dr. Susan Jebb.
This pace of regain suggests a return to pre-treatment mass in about 18 months.
Analyzing Treatments
The study, which looked at dozens of studies involving thousands of participants, contrasted the effects of these new drugs with conventional dieting.
Scientists point out that people who shed pounds through diet and exercise usually experience a slower weight regain—around 0.1 kg a month—post-intervention.
Explaining the Rapid Regain
Nutrition scientists believe the mechanism of the injections is key to understanding the amplified regain.
These medications copy a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of the hormone concentrations far above than the body's typical production may cause the system to produce less of its endogenous hormone, and may also reduce responsiveness to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication results in appetite is no longer kept in check, making binge eating much more probable."
An Ongoing Issue?
Health authorities recommend the jabs for individuals with weight-linked health risks, alongside recommended lifestyle changes.
Many experts say that, given the high risk of weight regain, the treatment is often long-term.
This view is reinforced by pharmaceutical companies, who say that the findings "underscore the chronic nature of excess weight," akin to managing diseases like hypertension.
Patient Experiences
Users who have discontinued the jabs explain a powerful resurgence of cravings.
"It was like a trigger activating and I was suddenly extremely hungry," said one woman.
This difficulty is worsened if individuals have not adopted sustainable lifestyle or habit modifications during treatment.
Widespread Adoption
Figures suggest that millions of adults in the UK have tried these injections in the past year, with interest remaining high.
- Use is more common among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- Many obtain the medications through private prescriptions rather than the NHS.
Ultimately, experts emphasize that while these medications are powerful tools for weight loss, they are not a standalone cure and lasting health benefits hinges on ongoing lifestyle changes.
